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Related post: influx also appears to be a component of the stimulatory effect; the stimulatory
component is not a pseudomonas elastase. It is also possible that prostaglandin
E could be acting as an inhibitor of mucin Buy Elimite secretion stimulation.
Legionnaires Disease
AI 17815-03 B. H. Iglewski (Oregon Health Sciences University) : This investi-
gator earlier found that Legionella pneumophila (LP) produced an exotoxin of
unknown properties. She now reports that the colorless cytotoxin is produced in
good yield in a chemically defined medium; has a M.W. of 800, is heat stable and
resistant to acid, alkali and enzymatic action. One microgram is toxic for
Chinese hamster ovary cells in Elimite Lotion culture. Other data show that the toxin adversely
affects the ability of PMNs and human monocytes to activate their oxygen-
dependent antimicrobial systems. The ability of LP to withstand the phagocytic-
antimicrobial action of these antimicrobial systems and survive intracellularly
most likely is related to the depression of these systems by the Legionella
toxin. The toxin may therefore play a Elimite Cream 5 significant role in the pathogenesis of I.
pneumophila infections.
AI 17254-03 M. A. Horwitz (Rockefeller University) : Earlier reports from
several investigators showed that patients with Legionnaires' disease (LD)
develop cell-mediated immunity to Legionella pneumophila (LP). Recent data imply
a limited role for humoral immunity and a major role in host defenses for cell-
mediated immunity. Electron microscope (EM) study by Dr. Horwitz showed that the
LP inhibits phagosome-lysosome fusion, and that erythromycin at concentrations
completely inhibiting intracellular LP multiplication had no effect on this
fusion process. Other EM studies revealed that the organism is phagocytized by a
7-5
highly unusual process in which a monocyte pseudopod is coiled around the
bacterium as it becomes internalized. Human monocytes, alveolar macrophages, and
PMNs all phagocytize the LP organism by this unusual process. The live LP
resides within the vacuoles containing other bacteria. Activation of the
monocytes does not influence the pH of the LP vacuole; this may help to
understand the mechanism by which LP survives and multiplies in host cells.
Staphylococcal Infections
ROl AI 14998-04 M. E. Melish (Kapiolani-Children's Medical Center) : Dr. Melish
has been studying staphylococcal epidermolytic toxin (ET) because of its
similarity to toxic shock syndrome and the scalded skin syndrome of infants. Her
recent data show that specific binding of ET occurs on membrane fractions of
human and murine skin; this binding is reversible and has a requirement for Cu
and Mg ions. The heat stable and heat labile forms of ET are chemically and
antigenically distinct. Receptor activity on membranes from the dermis as Elimite 5 well
as the epidermis demonstrate that receptors are not limited to all of the upper
epidermis, the site of action of the toxin. ET from streptococci also has been
isolated and purified; it has a M.W. of 30,000 daltons, differs chemically and
physically from all previously described streptocccal toxins, and is produced by
a majority of Group A beta-hemolytic streptococci. It is also found free in
blister fluid from patients with streptococcal cellulitis and in blister fluid
from a mouse model. The mechanism of action and location of binding sites is not
yet clear.
AI 17242-03 B. A. Sanford (University of Texas, San Antonio) : This project is
concerned with identifying the macromolecules responsible for the interaction of
bacterial respiratory pathogens with virus-infected mammalian cells (bacterial
superinfection). The experimental model involves canine kidney cell cultures
infected with various strains of influenza A virus that are then exposed to
radio-labeled bacterial Elimite Permethrin pathogens - Staphylococcus aureus Buy Elimite Online or Group A Elimite Cream Price or B
streptococci. In summary. Dr. Sanford 's data show that two distinct mechanisms
may be involved in which influenza A virus-infected cells can promote the
adherence of bacterial respiratory pathogens jjn Scabies Elimite vitro . First, virus infection
induces the appearance of cell membrane receptors that interact with bacterial
adhesins. Second, virus infection Elimite Cream induces the appearance of membrane receptors
that interact with fibrinogen that can, in turn, cross-link certain bacteria to
the cell surface. These mechanisms, if found to occur in vivo , could explain the
observed association between influenza A virus infection and the subsequent
bacterial superinfection with S^. aureus and Group A streptococcus.
Basic Research
5 ROl AI 15244-05 W. E. C. Moore (Virginia Polytechnic Institute) : Dr. Moore is
developing a method for rapid identification of clinical bacterial isolates based
on analysis of electrophoretic protein patterns of bacterial cultures. Current
data show that these patterns from a very broad range of bacteria provide
invaluable confirmation of identification by extensive classical biochemical
tests. In some instances, the patterns distinguished genetically unrelated
species that cannot be differentiated by conventional biochemical tests.
Computer programs to accept laser scans of the electrophoresis gels are now
operative in the investigators laboratory; initial computer programs have already
been written for comparisons of "unknown" strains with reference strains.
7-6
Development for wide clinical application will depend on computer pattern
recognition. Although incomplete, the data are encouraging for increasing
evidence and documentation that a reliable, rapid and inexpensive diagnostic
procedure can be developed.
Leprosy
NOl AI 22682 P. J. Brennan (Colorado State University, Fort Collins) : Dr.
Brennan has continued to characterize the species-specific glycol ipid antigens of
Mycobacterium leprae . Upon "dissecting" the glycol ipid-I molecule, he found that
trie lipid core was devoid of serological activity and the trisaccharide Order Elimite entity
was the serological determinant. This trisaccharide has been chemically
synthesized in the laboratory and coupled to bovine serum albumin. The synthetic
antigen is highly reactive (ELISA test) with leprosy patients' sera, but shows no
activity with normal human sera, or that from tuberculosis patients or from
patients infected with atypical mycobacteria. This antigen is of value in the
serological diagnosis of leprosy, if the antigen is protective, it also may be
useful in the development of an effective leprosy vaccine.
R22 AI 19302-01 B. J. Gormus (Tulane University, Louisiana) : Dr. Gormus found
that adult sooty mangabey monkeys inoculated with M. leprae (human origin)
developed skin lesions and other symptoms identical to human leprosy; they also
required drug therapy to control the disease. This should be an extremely useful
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